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In 1828 Scotland, Edinburgh surgeon Dr. Knox does medical research on cadavers he buys from murderers Burke and Hare, without questioning the unethical procurement methods.。何家千金何知意与薛齐瑞本将成婚，妹妹何知雨因爱生妒，伙同他人陷害何知意。婚礼前三天，何知雨派人拍何知意不堪照并威胁她。何知意为保护家人拒绝薛齐瑞求婚。之后她产双胞胎，因孩子患心脏病且自己经济有限，将女儿暖暖送薛齐瑞，儿子叁叁自己留着。。